Adaptive selection of a prion strain conformer corresponding to established North American CWD during propagation of novel emergent Norwegian strains in mice expressing elk or deer prion protein.

Adaptive selection of a prion strain conformer corresponding to established North American CWD during propagation of novel emergent Norwegian strains in mice expressing elk or deer prion protein.

Prions are infectious proteins causing fatal, transmissible neurodegenerative diseases of animals and humans. Replication involves template-directed refolding of host encoded prion protein, PrPC, by its infectious conformation, PrPSc. Following its discovery in captive Colorado deer in 1967, uncontr...

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Bibliographic Details
Main Authors: Jifeng Bian, Sehun Kim, Sarah J Kane, Jenna Crowell, Julianna L Sun, Jeffrey Christiansen, Eri Saijo, Julie A Moreno, James DiLisio, Emily Burnett, Sandra Pritzkow, Damian Gorski, Claudio Soto, Terry J Kreeger, Aru Balachandran, Gordon Mitchell, Michael W Miller, Romolo Nonno, Turid Vikøren, Jørn Våge, Knut Madslien, Linh Tran, Tram Thu Vuong, Sylvie L Benestad, Glenn C Telling
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-07-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1009748

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https://doi.org/10.1371/journal.ppat.1009748

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