Endocytosis of flavivirus NS1 is required for NS1-mediated endothelial hyperpermeability and is abolished by a single N-glycosylation site mutation.

Endocytosis of flavivirus NS1 is required for NS1-mediated endothelial hyperpermeability and is abolished by a single N-glycosylation site mutation.

Arthropod-borne flaviviruses cause life-threatening diseases associated with endothelial hyperpermeability and vascular leak. We recently found that vascular leak can be triggered by dengue virus (DENV) non-structural protein 1 (NS1) via the disruption of the endothelial glycocalyx-like layer (EGL)....

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Bibliographic Details
Main Authors: Chunling Wang, Henry Puerta-Guardo, Scott B Biering, Dustin R Glasner, Edwina B Tran, Mark Patana, Trent A Gomberg, Carmel Malvar, Nicholas T N Lo, Diego A Espinosa, Eva Harris
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-07-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1007938

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https://doi.org/10.1371/journal.ppat.1007938

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