Adaptive lymphocyte profiles correlate to brain Aβ burden in patients with mild cognitive impairment

Adaptive lymphocyte profiles correlate to brain Aβ burden in patients with mild cognitive impairment

Abstract Background We previously found that subjects with amnestic mild cognitive impairment exhibit a pro-inflammatory immune profile in the cerebrospinal fluid similar to multiple sclerosis, a central nervous system autoimmune disease. We therefore hypothesized that early neuroinflammation would...

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Bibliographic Details
Main Authors: Ann M. Stowe, Sara J. Ireland, Sterling B. Ortega, Ding Chen, Ryan M. Huebinger, Takashi Tarumi, Thomas S. Harris, C. Munro Cullum, Roger Rosenberg, Nancy L. Monson, Rong Zhang
Format: Article
Language:English
Published: BMC 2017-07-01
Series:Journal of Neuroinflammation
Subjects:
Amnestic mild cognitive impairment
Amyloid burden
18F-florbetapir
Memory B cells
IgG
T lymphocytes
Online Access:http://link.springer.com/article/10.1186/s12974-017-0910-x

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http://link.springer.com/article/10.1186/s12974-017-0910-x

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