β-catenin promotes MTX resistance of leukemia cells by down-regulating FPGS expression via NF-κB

β-catenin promotes MTX resistance of leukemia cells by down-regulating FPGS expression via NF-κB

Abstract Background Aberrant activation of β-catenin has been shown to play important roles in the chemoresistance of acute lymphoblastic leukemia (ALL), but the involvement and mechanism of β-catenin in methotrexate (MTX) resistance is poorly understood. In the present study, we demonstrate a criti...

Full description

Bibliographic Details
Main Authors: Shu-Guang Liu, Zhi-Xia Yue, Zhi-Gang Li, Rui-Dong Zhang, Hu-Yong Zheng, Xiao-Xi Zhao, Chao Gao
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Cancer Cell International
Subjects:
Acute lymphoblastic leukemia
Drug resistance
Folylpolyglutamate synthetase
Methotrexate
β-catenin
Online Access:http://link.springer.com/article/10.1186/s12935-020-01364-y

Internet

http://link.springer.com/article/10.1186/s12935-020-01364-y

Similar Items