Npc1 acting in neurons and glia is essential for the formation and maintenance of CNS myelin.
Cholesterol availability is rate-limiting for myelination, and prior studies have established the importance of cholesterol synthesis by oligodendrocytes for normal CNS myelination. However, the contribution of cholesterol uptake through the endocytic pathway has not been fully explored. To address...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2013-04-01
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| Series: | PLoS Genetics |
| Online Access: | http://europepmc.org/articles/PMC3623760?pdf=render |