MLH1 enhances the sensitivity of human endometrial carcinoma cells to cisplatin by activating the MLH1/c-Abl apoptosis signaling pathway

MLH1 enhances the sensitivity of human endometrial carcinoma cells to cisplatin by activating the MLH1/c-Abl apoptosis signaling pathway

Abstract Background MLH1 plays a critical role in maintaining the fidelity of DNA replication, and defects in human MLH1 have been reported. However, the role of MLH1 in endometrial carcinoma has not been fully investigated. Therefore, we aimed to study the role of MLH1 in the sensitivity of human e...

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Bibliographic Details
Main Authors: Yue Li, Shihong Zhang, Yuanjian Wang, Jin Peng, Fang Fang, Xingsheng Yang
Format: Article
Language:English
Published: BMC 2018-12-01
Series:BMC Cancer
Subjects:
Endometrial carcinoma
siRNA-MLH1
ADV-MLH1
Cisplatin sensitivity
Individualized therapy
Online Access:http://link.springer.com/article/10.1186/s12885-018-5218-4

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http://link.springer.com/article/10.1186/s12885-018-5218-4

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