Significance of druggable targets (PD-L1, KRAS, BRAF, PIK3CA, MSI, and HPV) on curatively resected esophageal squamous cell carcinoma

Significance of druggable targets (PD-L1, KRAS, BRAF, PIK3CA, MSI, and HPV) on curatively resected esophageal squamous cell carcinoma

Abstract Background Esophageal squamous cell carcinoma (ESCC) still remains intractable disease with few therapeutic options. Programmed death-ligand 1 (PD-L1), which is essential for immune evasion, is involved in the pathogenesis of ESCC and thus is a potential therapeutic target. PIK3CA, KRAS, an...

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Main Authors: Hong Kyu Lee, Mi Jung Kwon, Yong Joon Ra, Hee Sung Lee, Hyoung Soo Kim, Eun Sook Nam, Seong Jin Cho, Hye-Rim Park, Soo Kee Min, Jinwon Seo, Ji-Young Choe, Kyueng-Whan Min, So Young Kang
Format: Article
Language:English
Published: BMC 2020-10-01
Series:Diagnostic Pathology
Subjects:
Programmed death-ligand 1
Esophagus
Squamous cell carcinoma
Microsatellite instability
Human papillomavirus
PIK3CA
Online Access:http://link.springer.com/article/10.1186/s13000-020-01045-4

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http://link.springer.com/article/10.1186/s13000-020-01045-4

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