Targeted delivery of GDNF through the blood-brain barrier by MRI-guided focused ultrasound.

Targeted delivery of GDNF through the blood-brain barrier by MRI-guided focused ultrasound.

Neurotrophic factors, such as glial cell line-derived neurotrophic factor (GDNF), are promising therapeutic agents for neurodegenerative diseases. However, the application of GDNF to treat these diseases effectively is limited because the blood-brain barrier (BBB) prevents the local delivery of macr...

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Bibliographic Details
Main Authors: Feng Wang, Yu Shi, Lin Lu, Li Liu, Youli Cai, Hairong Zheng, Xin Liu, Fei Yan, Chao Zou, Chengyu Sun, Jie Shi, Shukun Lu, Yun Chen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3531370?pdf=render

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http://europepmc.org/articles/PMC3531370?pdf=render

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