Herpes simplex type 2 virus deleted in glycoprotein D protects against vaginal, skin and neural disease

Herpes simplex type 2 virus deleted in glycoprotein D protects against vaginal, skin and neural disease

Subunit vaccines comprised of glycoprotein D (gD-2) failed to prevent HSV-2 highlighting need for novel strategies. To test the hypothesis that deletion of gD-2 unmasks protective antigens, we evaluated the efficacy and safety of an HSV-2 virus deleted in gD-2 and complemented allowing a single roun...

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Bibliographic Details
Main Authors: Christopher Petro, Pablo A González, Natalia Cheshenko, Thomas Jandl, Nazanin Khajoueinejad, Angèle Bénard, Mayami Sengupta, Betsy C Herold, William R Jacobs Jr
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-03-01
Series:eLife
Subjects:
vaccine
HSV-2
virology
antibody
immunity
Online Access:https://elifesciences.org/articles/06054

Internet

https://elifesciences.org/articles/06054

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