Medroxyprogesterone Reverses Tolerable Dose Metformin-Induced Inhibition of Invasion via Matrix Metallopeptidase-9 and Transforming Growth Factor-β1 in KLE Endometrial Cancer Cells

Medroxyprogesterone Reverses Tolerable Dose Metformin-Induced Inhibition of Invasion via Matrix Metallopeptidase-9 and Transforming Growth Factor-β1 in KLE Endometrial Cancer Cells

This study was performed to evaluate the anticancer effects of tolerable doses of metformin with or without medroxyprogesterone (MPA) in endometrial cancer cells. Cell viability, cell invasion, and levels of matrix metallopeptidase (MMP) and transforming growth factor (TGF)-β1 were analyzed using th...

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Bibliographic Details
Main Authors: Dong Hoon Suh, Sunray Lee, Hyun-Sook Park, Noh Hyun Park
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Journal of Clinical Medicine
Subjects:
metformin
medroxyprogesterone
endometrial cancer
invasion
matrix metallopeptidase-9
transforming growth factor-β1
Online Access:https://www.mdpi.com/2077-0383/9/11/3585

Internet

https://www.mdpi.com/2077-0383/9/11/3585

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