Urinary Cell Adhesion Molecule 1 Is a Novel Biomarker That Links Tubulointerstitial Damage to Glomerular Filtration Rates in Chronic Kidney Disease

Urinary Cell Adhesion Molecule 1 Is a Novel Biomarker That Links Tubulointerstitial Damage to Glomerular Filtration Rates in Chronic Kidney Disease

Cell adhesion molecule 1 (CADM1) is an immunoglobulin superfamily member strongly expressed on renal tubular epithelia in the urinary tract. Enzymatic cleavage of its ectodomain increases in chronic kidney disease (CKD), and is assumed to contribute to tubulointerstitial lesion formation. Because th...

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Bibliographic Details
Main Authors: Man Hagiyama, Yoshihisa Nakatani, Yasutoshi Takashima, Takashi Kato, Takao Inoue, Ryuichiro Kimura, Tomoyuki Otani, Yasufumi Sato, Hideo Mori, Shuji Arima, Akihiko Ito
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
chronic kidney disease
tubulointerstitial lesion
cell adhesion molecule 1
ectodomain shedding
ELISA
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2019.00111/full

Internet

https://www.frontiersin.org/article/10.3389/fcell.2019.00111/full

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