Detecting protein variants by mass spectrometry: a comprehensive study in cancer cell-lines

Detecting protein variants by mass spectrometry: a comprehensive study in cancer cell-lines

Abstract Background Onco-proteogenomics aims to understand how changes in a cancer’s genome influences its proteome. One challenge in integrating these molecular data is the identification of aberrant protein products from mass-spectrometry (MS) datasets, as traditional proteomic analyses only ident...

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Bibliographic Details
Main Authors: Javier A. Alfaro, Alexandr Ignatchenko, Vladimir Ignatchenko, Ankit Sinha, Paul C. Boutros, Thomas Kislinger
Format: Article
Language:English
Published: BMC 2017-07-01
Series:Genome Medicine
Subjects:
Proteogenomics
Proteoforms
Protein mutant detection
Integrative –omics
Protein search databases
Personalized proteomics
Online Access:http://link.springer.com/article/10.1186/s13073-017-0454-9

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http://link.springer.com/article/10.1186/s13073-017-0454-9

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