Antidepressant-Like Effects of Chronic Guanosine in the Olfactory Bulbectomy Mouse Model

Antidepressant-Like Effects of Chronic Guanosine in the Olfactory Bulbectomy Mouse Model

Major depressive disorder (MDD) leads to pervasive changes in the health of afflicted patients. Despite advances in the understanding of MDD and its treatment, profound innovation is needed to develop fast-onset antidepressants with higher effectiveness. When acutely administered, the endogenous nuc...

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Bibliographic Details
Main Authors: Roberto Farina Almeida, Yasmine Nonose, Marcelo Ganzella, Samanta Oliveira Loureiro, Andréia Rocha, Daniele Guilhermano Machado, Bruna Bellaver, Fernanda Urruth Fontella, Douglas T. Leffa, Letícia Ferreira Pettenuzzo, Gianina Teribele Venturin, Samuel Greggio, Jaderson Costa da Costa, Eduardo R. Zimmer, Elaine Elisabetsky, Diogo O. Souza
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Psychiatry
Subjects:
major depressive disorder
psychopharmacology
purines (source: MeSH)
guanosine
purinergic signaling
olfactory bulbectomy
Online Access:https://www.frontiersin.org/articles/10.3389/fpsyt.2021.701408/full

Internet

https://www.frontiersin.org/articles/10.3389/fpsyt.2021.701408/full

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