Vectofusin-1 Promotes RD114-TR-Pseudotyped Lentiviral Vector Transduction of Human HSPCs and T Lymphocytes

Vectofusin-1 Promotes RD114-TR-Pseudotyped Lentiviral Vector Transduction of Human HSPCs and T Lymphocytes

Ex vivo transduction of human CD34+ hematopoietic stem/progenitor cells (hCD34+ HSPCs) and T lymphocytes is a key process that requires high efficiency and low toxicity to achieve effective clinical results. So far, several enhancers have been used to improve this process. Among them, Retronectin hi...

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Bibliographic Details
Main Authors: Claudia Piovan, Virna Marin, Cinzia Scavullo, Stefano Corna, Erica Giuliani, Sergio Bossi, Anne Galy, David Fenard, Claudio Bordignon, Gian Paolo Rizzardi, Chiara Bovolenta
Format: Article
Language:English
Published: Elsevier 2017-06-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
lentiviral vector
transduction
HSC
T lymphocytes
additive
peptide
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050117300438

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http://www.sciencedirect.com/science/article/pii/S2329050117300438

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