Deletion of <i>Irf4</i> in T Cells Suppressed Autoimmune Uveitis and Dysregulated Transcriptional Programs Linked to CD4<sup>+</sup> T Cell Differentiation and Metabolism

Deletion of <i>Irf4</i> in T Cells Suppressed Autoimmune Uveitis and Dysregulated Transcriptional Programs Linked to CD4<sup>+</sup> T Cell Differentiation and Metabolism

Interferon regulatory factor-4 (IRF4) and IRF8 regulate differentiation, growth and functions of lymphoid and myeloid cells. Targeted deletion of <i>irf8 </i>in T cells (CD4-IRF8KO) has been shown to exacerbate colitis and experimental autoimmune uveitis (EAU), a mouse model of human uve...

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Bibliographic Details
Main Authors: Minkyung Kang, Hyun-Su Lee, Jin Kyeong Choi, Cheng-Rong Yu, Charles E. Egwuagu
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:International Journal of Molecular Sciences
Subjects:
CD4
IRF4
Autoimmune Uveitis
IkZFs
IL35
metabolism
Online Access:https://www.mdpi.com/1422-0067/22/5/2775

Internet

https://www.mdpi.com/1422-0067/22/5/2775

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