The atypical cyclin-like protein Spy1 overrides p53-mediated tumour suppression and promotes susceptibility to breast tumourigenesis

The atypical cyclin-like protein Spy1 overrides p53-mediated tumour suppression and promotes susceptibility to breast tumourigenesis

Abstract Background Breast cancer is the most common cancer to affect women and one of the leading causes of cancer-related deaths. Proper regulation of cell cycle checkpoints plays a critical role in preventing the accumulation of deleterious mutations. Perturbations in the expression or activity o...

Full description

Bibliographic Details
Main Authors: Bre-Anne Fifield, Ingrid Qemo, Evie Kirou, Robert D. Cardiff, Lisa Ann Porter
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Breast Cancer Research
Subjects:
Cdk
Cyclin
Cell cycle
Tumour suppressor
Mammary gland
DNA damage
Online Access:https://doi.org/10.1186/s13058-019-1211-3

Internet

https://doi.org/10.1186/s13058-019-1211-3

Similar Items