Increased peptide contacts govern high affinity binding of a modified TCR whilst maintaining a native pMHC docking mode
Natural TCRs generally bind to their cognate pMHC molecules with weak affinity and fast kinetics, limiting their use as therapeutic agents. Using phage display, we have engineered a high affinity version of the A6 wildtype TCR (A6wt), specific for the human leukocyte antigen (HLA-A*0201) complexed w...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2013-06-01
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| Series: | Frontiers in Immunology |
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| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fimmu.2013.00168/full |