Vitamin E Dietary Supplementation Improves Neurological Symptoms and Decreases c-Abl/p73 Activation in Niemann-Pick C Mice

Vitamin E Dietary Supplementation Improves Neurological Symptoms and Decreases c-Abl/p73 Activation in Niemann-Pick C Mice

Niemann-Pick C (NPC) disease is a fatal neurodegenerative disorder characterized by the accumulation of free cholesterol in lysosomes. We have previously reported that oxidative stress is the main upstream stimulus activating the proapoptotic c-Abl/p73 pathway in NPC neurons. We have also observed...

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Bibliographic Details
Main Authors: Tamara Marín, Pablo Contreras, Juan Francisco Castro, David Chamorro, Elisa Balboa, Mònica Bosch-Morató, Francisco J. Muñoz, Alejandra R. Alvarez, Silvana Zanlungo
Format: Article
Language:English
Published: MDPI AG 2014-07-01
Series:Nutrients
Subjects:
vitamin E
Niemann-Pick C
cholesterol
lysosomes
apoptosis
c-Abl
Online Access:http://www.mdpi.com/2072-6643/6/8/3000

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http://www.mdpi.com/2072-6643/6/8/3000

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