Maternal Choline and Betaine Supplementation Modifies the Placental Response to Hyperglycemia in Mice and Human Trophoblasts

Maternal Choline and Betaine Supplementation Modifies the Placental Response to Hyperglycemia in Mice and Human Trophoblasts

Gestational diabetes mellitus (GDM) is characterized by excessive placental fat and glucose transport, resulting in fetal overgrowth. Earlier we demonstrated that maternal choline supplementation normalizes fetal growth in GDM mice at mid-gestation. In this study, we further assess how choline and i...

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Bibliographic Details
Main Authors: Khatia Nanobashvili, Chauntelle Jack-Roberts, Rachel Bretter, Naudia Jones, Kathleen Axen, Anjana Saxena, Kali Blain, Xinyin Jiang
Format: Article
Language:English
Published: MDPI AG 2018-10-01
Series:Nutrients
Subjects:
choline
betaine
gestational diabetes
placental morphology
nutrient transport
vasculature
Online Access:http://www.mdpi.com/2072-6643/10/10/1507

Internet

http://www.mdpi.com/2072-6643/10/10/1507

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