Leukocyte ABCA1 remains atheroprotective in splenectomized LDL receptor knockout mice.

Leukocyte ABCA1 remains atheroprotective in splenectomized LDL receptor knockout mice.

ATP-binding cassette transporter A1 (ABCA1) is an important mediator of macrophage cholesterol efflux. It mediates the efflux of cellular cholesterol to lipid-poor apolipoprotein A-I. LDL receptor (LDLr) knockout (KO) mice deficient for leukocyte ABCA1 (ABCA1 KO→LDLr KO) show increased atheroscleros...

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Bibliographic Details
Main Authors: Bart Lammers, Ying Zhao, Amanda C Foks, Reeni B Hildebrand, Johan Kuiper, Theo J C Van Berkel, Miranda Van Eck
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3485037?pdf=render

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http://europepmc.org/articles/PMC3485037?pdf=render

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