Role of Plasmodium falciparum Protein GEXP07 in Maurer’s Cleft Morphology, Knob Architecture, and P. falciparum EMP1 Trafficking

Role of Plasmodium falciparum Protein GEXP07 in Maurer’s Cleft Morphology, Knob Architecture, and P. falciparum EMP1 Trafficking

The trafficking of the virulence antigen PfEMP1 and its presentation at the knob structures at the surface of parasite-infected RBCs are central to severe adhesion-related pathologies such as cerebral and placental malaria. This work adds to our understanding of how PfEMP1 is trafficked to the RBC m...

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Bibliographic Details
Main Authors: Emma McHugh, Olivia M. S. Carmo, Adam Blanch, Oliver Looker, Boyin Liu, Snigdha Tiash, Dean Andrew, Steven Batinovic, Andy J. Y. Low, Hyun-Jung Cho, Paul McMillan, Leann Tilley, Matthew W. A. Dixon
Format: Article
Language:English
Published: American Society for Microbiology 2020-03-01
Series:mBio
Subjects:
malaria
protein trafficking
virulence determinants
Online Access:https://doi.org/10.1128/mBio.03320-19

Internet

https://doi.org/10.1128/mBio.03320-19

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