HIV Tat controls RNA Polymerase II and the epigenetic landscape to transcriptionally reprogram target immune cells

HIV Tat controls RNA Polymerase II and the epigenetic landscape to transcriptionally reprogram target immune cells

HIV encodes Tat, a small protein that facilitates viral transcription by binding an RNA structure (trans-activating RNA [TAR]) formed on nascent viral pre-messenger RNAs. Besides this well-characterized mechanism, Tat appears to modulate cellular transcription, but the target genes and molecular mec...

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Bibliographic Details
Main Authors: Jonathan E Reeder, Youn-Tae Kwak, Ryan P McNamara, Christian V Forst, Iván D'Orso
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-10-01
Series:eLife
Subjects:
transcription factor
chromatin
RNA polymerase II
epigenetic
transcription
Online Access:https://elifesciences.org/articles/08955

Internet

https://elifesciences.org/articles/08955

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