Transdermal delivery of 4-aminopyridine accelerates motor functional recovery and improves nerve morphology following sciatic nerve crush injury in mice

Transdermal delivery of 4-aminopyridine accelerates motor functional recovery and improves nerve morphology following sciatic nerve crush injury in mice

Oral 4-aminopyridine (4-AP) is clinically used for symptomatic relief in multiple sclerosis and we recently demonstrated that systemic 4-AP had previously unknown clinically-relevant effects after traumatic peripheral nerve injury including the promotion of re-myelination, improvement of nerve condu...

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Bibliographic Details
Main Authors: Andrew R Clark, Chia George Hsu, M A Hassan Talukder, Mark Noble, John C Elfar
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2020-01-01
Series:Neural Regeneration Research
Subjects:
4-aminopyridine; electron microscopy; functional recovery; nerve conduction velocity; peripheral nerve injury; pharmacokinetics; transdermal administration
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2020;volume=15;issue=1;spage=136;epage=144;aulast=Clark

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http://www.nrronline.org/article.asp?issn=1673-5374;year=2020;volume=15;issue=1;spage=136;epage=144;aulast=Clark

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