The multi-functional reovirus σ3 protein is a virulence factor that suppresses stress granule formation and is associated with myocardial injury.

The multi-functional reovirus σ3 protein is a virulence factor that suppresses stress granule formation and is associated with myocardial injury.

The mammalian orthoreovirus double-stranded (ds) RNA-binding protein σ3 is a multifunctional protein that promotes viral protein synthesis and facilitates viral entry and assembly. The dsRNA-binding capacity of σ3 correlates with its capacity to prevent dsRNA-mediated activation of protein kinase R...

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Bibliographic Details
Main Authors: Yingying Guo, Meleana M Hinchman, Mercedes Lewandrowski, Shaun T Cross, Danica M Sutherland, Olivia L Welsh, Terence S Dermody, John S L Parker
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-07-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1009494

Internet

https://doi.org/10.1371/journal.ppat.1009494

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