STAT5a/b Deficiency Delays, but does not Prevent, Prolactin-Driven Prostate Tumorigenesis in Mice

STAT5a/b Deficiency Delays, but does not Prevent, Prolactin-Driven Prostate Tumorigenesis in Mice

The canonical prolactin (PRL) Signal Transducer and Activator of Transcription (STAT) 5 pathway has been suggested to contribute to human prostate tumorigenesis via an autocrine/paracrine mechanism. The probasin (Pb)-PRL transgenic mouse models this mechanism by overexpressing PRL specifically in th...

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Bibliographic Details
Main Authors: Florence Boutillon, Natascha Pigat, Lucila Sackmann Sala, Edouard Reyes-Gomez, Richard Moriggl, Jacques-Emmanuel Guidotti, Vincent Goffin
Format: Article
Language:English
Published: MDPI AG 2019-07-01
Series:Cancers
Subjects:
STAT5
AKT
ERK1/2
prolactin
androgens
prostate cancer
knockout
escape mechanisms
stem/progenitor cells
cell hierarchy
Online Access:https://www.mdpi.com/2072-6694/11/7/929

Internet

https://www.mdpi.com/2072-6694/11/7/929

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