Benzoxaborole treatment perturbs S-adenosyl-L-methionine metabolism in Trypanosoma brucei.

Benzoxaborole treatment perturbs S-adenosyl-L-methionine metabolism in Trypanosoma brucei.

The parasitic protozoan Trypanosoma brucei causes Human African Trypanosomiasis and Nagana in other mammals. These diseases present a major socio-economic burden to large areas of sub-Saharan Africa. Current therapies involve complex and toxic regimens, which can lead to fatal side-effects. In addit...

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Bibliographic Details
Main Authors: Pieter C Steketee, Isabel M Vincent, Fiona Achcar, Federica Giordani, Dong-Hyun Kim, Darren J Creek, Yvonne Freund, Robert Jacobs, Kevin Rattigan, David Horn, Mark C Field, Annette MacLeod, Michael P Barrett
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-05-01
Series:PLoS Neglected Tropical Diseases
Online Access:https://doi.org/10.1371/journal.pntd.0006450

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https://doi.org/10.1371/journal.pntd.0006450

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