Design, Synthesis, and Cytotoxicity Assessment of [<sup>64</sup>Cu]Cu-NOTA-Terpyridine Platinum Conjugate: A Novel Chemoradiotherapeutic Agent with Flexible Linker

Design, Synthesis, and Cytotoxicity Assessment of [<sup>64</sup>Cu]Cu-NOTA-Terpyridine Platinum Conjugate: A Novel Chemoradiotherapeutic Agent with Flexible Linker

Maximum benefits of chemoradiation therapy with platinum-based compounds are expected if the radiation and the drug are localized simultaneously in cancer cells. To optimize this concomitant effect, we developed the novel chemoradiotherapeutic agent [<sup>64</sup>Cu]Cu-NOTA-C3-TP by conj...

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Bibliographic Details
Main Authors: Meysam Khosravifarsani, Samia Ait-Mohand, Benoit Paquette, Léon Sanche, Brigitte Guérin
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Nanomaterials
Subjects:
copper-64
chemoradiotherapeutic agent
cytotoxic activity
platinum-based compounds
terpyridine platinum
low energy electrons
Online Access:https://www.mdpi.com/2079-4991/11/9/2154

Internet

https://www.mdpi.com/2079-4991/11/9/2154

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