A recombinant rabies virus encoding two copies of the glycoprotein gene confers protection in dogs against a virulent challenge.

A recombinant rabies virus encoding two copies of the glycoprotein gene confers protection in dogs against a virulent challenge.

The rabies virus (RABV) glycoprotein (G) is the principal antigen responsible for the induction of virus neutralizing antibodies (VNA) and is the major modality of protective immunity in animals. A recombinant RABV HEP-Flury strain was generated by reverse genetics to encode two copies of the G-gene...

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Bibliographic Details
Main Authors: Xiaohui Liu, Youtian Yang, Zhaojin Sun, Jing Chen, Jun Ai, Can Dun, Zhen F Fu, Xuefeng Niu, Xiaofeng Guo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3911940?pdf=render

Internet

http://europepmc.org/articles/PMC3911940?pdf=render

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