Comparative Analysis of Microfluidics Thrombus Formation in Multiple Genetically Modified Mice: Link to Thrombosis and Hemostasis

Comparative Analysis of Microfluidics Thrombus Formation in Multiple Genetically Modified Mice: Link to Thrombosis and Hemostasis

Genetically modified mice are indispensable for establishing the roles of platelets in arterial thrombosis and hemostasis. Microfluidics assays using anticoagulated whole blood are commonly used as integrative proxy tests for platelet function in mice. In the present study, we quantified the changes...

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Bibliographic Details
Main Authors: Magdolna Nagy, Johanna P. van Geffen, David Stegner, David J. Adams, Attila Braun, Susanne M. de Witt, Margitta Elvers, Mitchell J. Geer, Marijke J. E. Kuijpers, Karl Kunzelmann, Jun Mori, Cécile Oury, Joachim Pircher, Irina Pleines, Alastair W. Poole, Yotis A. Senis, Remco Verdoold, Christian Weber, Bernhard Nieswandt, Johan W. M. Heemskerk, Constance C. F. M. J. Baaten
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
arterial thrombus formation
bleeding
collagen
glycoprotein VI
platelets
microfluidics
Online Access:https://www.frontiersin.org/article/10.3389/fcvm.2019.00099/full

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https://www.frontiersin.org/article/10.3389/fcvm.2019.00099/full

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