A cDNA Clone-Launched Platform for High-Yield Production of Inactivated Zika Vaccine

A cDNA Clone-Launched Platform for High-Yield Production of Inactivated Zika Vaccine

A purified inactivated vaccine (PIV) using the Zika virus (ZIKV) Puerto Rico strain PRVABC59 showed efficacy in monkeys, and is currently in a phase I clinical trial. High-yield manufacture of this PIV is essential for its development and vaccine access. Here we report an infectious cDNA clone-launc...

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Bibliographic Details
Main Authors: Yujiao Yang, Chao Shan, Jing Zou, Antonio E. Muruato, Diniz Nunes Bruno, Barbosa de Almeida Medeiros Daniele, Pedro F.C. Vasconcelos, Shannan L. Rossi, Scott C. Weaver, Xuping Xie, Pei-Yong Shi
Format: Article
Language:English
Published: Elsevier 2017-03-01
Series:EBioMedicine
Subjects:
Zika virus vaccine
Flavivirus NS1
Flavivirus assembly
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396417300610

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http://www.sciencedirect.com/science/article/pii/S2352396417300610

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