Promotion or Suppression of Murine Intestinal Polyp Development by iNKT Cell Directed Immunotherapy

Promotion or Suppression of Murine Intestinal Polyp Development by iNKT Cell Directed Immunotherapy

The glycosphingolipid α-galactosylceramide (α-GalCer) is a well-described immune activator with strong anti-tumor properties in animal models. It is presented on CD1d and acts by stimulating the invariant, type I, natural killer T (iNKT) lymphocytes to rapidly secrete TH1 and TH2 associated cytokine...

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Bibliographic Details
Main Authors: Ying Wang, Saikiran K. Sedimbi, Linda Löfbom, Gurdyal S. Besra, Steven A. Porcelli, Susanna L. Cardell
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Immunology
Subjects:
NKT cells
tumor immunotherapy
intestine
α-galactosylceramide
CD1d
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00352/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.00352/full

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