A DNMT3A PWWP mutation leads to methylation of bivalent chromatin and growth retardation in mice
PWWP domains of DNMT3A and DNMT3B are proposed to interact with H3K36me3. Here the authors present a mouse model carrying a D329A point mutation in the DNMT3A PWWP domain and find this causes dominant postnatal growth retardation, with aberrant progressive gain of DNA methylation across domains mark...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2019-04-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-09713-w |