A DNMT3A PWWP mutation leads to methylation of bivalent chromatin and growth retardation in mice

A DNMT3A PWWP mutation leads to methylation of bivalent chromatin and growth retardation in mice

PWWP domains of DNMT3A and DNMT3B are proposed to interact with H3K36me3. Here the authors present a mouse model carrying a D329A point mutation in the DNMT3A PWWP domain and find this causes dominant postnatal growth retardation, with aberrant progressive gain of DNA methylation across domains mark...

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Main Authors: Gintarė Sendžikaitė, Courtney W. Hanna, Kathleen R. Stewart-Morgan, Elena Ivanova, Gavin Kelsey
Format: Article
Language:English
Published: Nature Publishing Group 2019-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-09713-w
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spelling doaj-bf208415af2e4e6986d414cb8d984ae32021-05-11T12:21:19ZengNature Publishing GroupNature Communications2041-17232019-04-0110111610.1038/s41467-019-09713-wA DNMT3A PWWP mutation leads to methylation of bivalent chromatin and growth retardation in miceGintarė Sendžikaitė0Courtney W. Hanna1Kathleen R. Stewart-Morgan2Elena Ivanova3Gavin Kelsey4Epigenetics Programme, Babraham InstituteEpigenetics Programme, Babraham InstituteEpigenetics Programme, Babraham InstituteEpigenetics Programme, Babraham InstituteEpigenetics Programme, Babraham InstitutePWWP domains of DNMT3A and DNMT3B are proposed to interact with H3K36me3. Here the authors present a mouse model carrying a D329A point mutation in the DNMT3A PWWP domain and find this causes dominant postnatal growth retardation, with aberrant progressive gain of DNA methylation across domains marked by H3K27me3 in adult tissues.https://doi.org/10.1038/s41467-019-09713-w
collection DOAJ
language English
format Article
sources DOAJ
author Gintarė Sendžikaitė
Courtney W. Hanna
Kathleen R. Stewart-Morgan
Elena Ivanova
Gavin Kelsey
spellingShingle Gintarė Sendžikaitė
Courtney W. Hanna
Kathleen R. Stewart-Morgan
Elena Ivanova
Gavin Kelsey
A DNMT3A PWWP mutation leads to methylation of bivalent chromatin and growth retardation in mice
Nature Communications
author_facet Gintarė Sendžikaitė
Courtney W. Hanna
Kathleen R. Stewart-Morgan
Elena Ivanova
Gavin Kelsey
author_sort Gintarė Sendžikaitė
title A DNMT3A PWWP mutation leads to methylation of bivalent chromatin and growth retardation in mice
title_short A DNMT3A PWWP mutation leads to methylation of bivalent chromatin and growth retardation in mice
title_full A DNMT3A PWWP mutation leads to methylation of bivalent chromatin and growth retardation in mice
title_fullStr A DNMT3A PWWP mutation leads to methylation of bivalent chromatin and growth retardation in mice
title_full_unstemmed A DNMT3A PWWP mutation leads to methylation of bivalent chromatin and growth retardation in mice
title_sort dnmt3a pwwp mutation leads to methylation of bivalent chromatin and growth retardation in mice
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2019-04-01
description PWWP domains of DNMT3A and DNMT3B are proposed to interact with H3K36me3. Here the authors present a mouse model carrying a D329A point mutation in the DNMT3A PWWP domain and find this causes dominant postnatal growth retardation, with aberrant progressive gain of DNA methylation across domains marked by H3K27me3 in adult tissues.
url https://doi.org/10.1038/s41467-019-09713-w
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