Multi-region and single-cell sequencing reveal variable genomic heterogeneity in rectal cancer

Multi-region and single-cell sequencing reveal variable genomic heterogeneity in rectal cancer

Abstract Background Colorectal cancer is a heterogeneous group of malignancies with complex molecular subtypes. While colon cancer has been widely investigated, studies on rectal cancer are very limited. Here, we performed multi-region whole-exome sequencing and single-cell whole-genome sequencing t...

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Bibliographic Details
Main Authors: Mingshan Liu, Yang Liu, Jiabo Di, Zhe Su, Hong Yang, Beihai Jiang, Zaozao Wang, Meng Zhuang, Fan Bai, Xiangqian Su
Format: Article
Language:English
Published: BMC 2017-11-01
Series:BMC Cancer
Subjects:
Rectal cancer
Single-cell whole-genome sequencing
Multi-region whole-exome sequencing
Somatic copy number alterations
Intratumor heterogeneity
Online Access:http://link.springer.com/article/10.1186/s12885-017-3777-4

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http://link.springer.com/article/10.1186/s12885-017-3777-4

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