NMR structure of the human prion protein with the pathological Q212P mutation reveals unique structural features.
Prion diseases are fatal neurodegenerative disorders caused by an aberrant accumulation of the misfolded cellular prion protein (PrP(C)) conformer, denoted as infectious scrapie isoform or PrP(Sc). In inherited human prion diseases, mutations in the open reading frame of the PrP gene (PRNP) are hypo...
Main Authors: | , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2010-01-01
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Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC2908606?pdf=render |