Coral-Derived Compound WA-25 Inhibits Angiogenesis by Attenuating the VEGF/VEGFR2 Signaling Pathway

Coral-Derived Compound WA-25 Inhibits Angiogenesis by Attenuating the VEGF/VEGFR2 Signaling Pathway

Background: WA-25 (dihydroaustrasulfone alcohol, a synthetic derivative of marine compound WE-2) suppresses atherosclerosis in rats by reducing neointima formation. Because angiogenesis plays a critical role in the pathogenesis of atherosclerosis, the present study investigated the angiogenic functi...

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Bibliographic Details
Main Authors: Shih-Wei Lin, Shih-Chung Huang, Hsiao-Mei Kuo, Chiu-Hua Chen, Yi-Ling Ma, Tian-Huei Chu, Youn-Shen Bee, E-Ming Wang, Chang-Yi Wu, Ping-Jyun Sung, Zhi-Hong Wen, Deng-Chyang Wu, Jyh-Horng Sheu, Ming-Hong Tai
Format: Article
Language:English
Published: MDPI AG 2015-02-01
Series:Marine Drugs
Subjects:
marine drugs
human umbilical vein endothelial cells (HUVECs)
vascular endothelial growth factor (VEGF)
VEGF receptor 2 (VEGFR2)
Online Access:http://www.mdpi.com/1660-3397/13/2/861

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http://www.mdpi.com/1660-3397/13/2/861

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