Recovery of Adrenal Insufficiency Is Frequent After Adjuvant Mitotane Therapy in Patients with Adrenocortical Carcinoma

Recovery of Adrenal Insufficiency Is Frequent After Adjuvant Mitotane Therapy in Patients with Adrenocortical Carcinoma

Mitotane is a steroidogenesis inhibitor and adrenolytic drug used for treatment of adrenocortical cancer (ACC). Mitotane therapy causes adrenal insufficiency requiring glucocorticoid replacement in all patients. However, it is unclear whether chronic therapy with mitotane induces complete destructio...

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Bibliographic Details
Main Authors: Jonathan Poirier, Nadia Gagnon, Massimo Terzolo, Soraya Puglisi, Nada El Ghorayeb, Anna Calabrese, André Lacroix, Isabelle Bourdeau
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Cancers
Subjects:
adrenocortical carcinoma
mitotane
hpa axis
Online Access:https://www.mdpi.com/2072-6694/12/3/639

Internet

https://www.mdpi.com/2072-6694/12/3/639

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