Influence of Casein kinase II inhibitor CX-4945 on BCL6-mediated apoptotic signaling in B-ALL in vitro and in vivo

Influence of Casein kinase II inhibitor CX-4945 on BCL6-mediated apoptotic signaling in B-ALL in vitro and in vivo

Abstract Background Casein kinase II (CK2) is involved in multiple tumor-relevant signaling pathways affecting proliferation and apoptosis. CK2 is frequently upregulated in acute B-lymphoblastic leukemia (B-ALL) and can be targeted by the ATP-competitive CK2 inhibitor CX-4945. While reduced prolifer...

Full description

Bibliographic Details
Main Authors: Anna Richter, Sina Sender, Annemarie Lenz, Rico Schwarz, Burkhard Hinz, Gudrun Knuebel, Anett Sekora, Hugo Murua Escobar, Christian Junghanss, Catrin Roolf
Format: Article
Language:English
Published: BMC 2020-03-01
Series:BMC Cancer
Subjects:
B-ALL
Apoptosis
CK2
CX-4945
BCL6
BACH2
Online Access:http://link.springer.com/article/10.1186/s12885-020-6650-9

Internet

http://link.springer.com/article/10.1186/s12885-020-6650-9

Similar Items