Telmisartan increases hepatic glucose production via protein kinase C ζ-dependent insulin receptor substrate-1 phosphorylation in HepG2 cells and mouse liver

Telmisartan increases hepatic glucose production via protein kinase C ζ-dependent insulin receptor substrate-1 phosphorylation in HepG2 cells and mouse liver

Background Dysregulation of hepatic glucose production (HGP) contributes to the development of type 2 diabetes mellitus. Telmisartan, an angiotensin II type 1 receptor blocker (ARB), has various ancillary effects in addition to common blood pressure-lowering effects. The effects and mechanism of tel...

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Bibliographic Details
Main Authors: Kae Won Cho, Du-Hyong Cho
Format: Article
Language:English
Published: Yeungnam University College of Medicine 2019-01-01
Series:Yeungnam University Journal of Medicine
Subjects:
Hepatic glucose production
IRS-1
Phosphorylation
PKCζ
Telmisartan
Online Access:http://yujm.yu.ac.kr/upload/pdf/yujm-2019-00059.pdf

Internet

http://yujm.yu.ac.kr/upload/pdf/yujm-2019-00059.pdf

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