Large-scale determination of previously unsolved protein structures using evolutionary information

Large-scale determination of previously unsolved protein structures using evolutionary information

The prediction of the structures of proteins without detectable sequence similarity to any protein of known structure remains an outstanding scientific challenge. Here we report significant progress in this area. We first describe de novo blind structure predictions of unprecendented accuracy we ma...

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Bibliographic Details
Main Authors: Sergey Ovchinnikov, Lisa Kinch, Hahnbeom Park, Yuxing Liao, Jimin Pei, David E Kim, Hetunandan Kamisetty, Nick V Grishin, David Baker
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-09-01
Series:eLife
Subjects:
co-evolution
structure prediction
protein fold
protein family
Online Access:https://elifesciences.org/articles/09248

Internet

https://elifesciences.org/articles/09248

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