Association of variants at BCL11A and HBS1L-MYB with hemoglobin F and hospitalization rates among sickle cell patients in Cameroon.

Genetic variation at loci influencing adult levels of HbF have been shown to modify the clinical course of sickle cell disease (SCD). Data on this important aspect of SCD have not yet been reported from West Africa. We investigated the relationship between HbF levels and the relevant genetic loci in...

Full description

Bibliographic Details
Main Authors: Ambroise Wonkam, Valentina J Ngo Bitoungui, Anna A Vorster, Raj Ramesar, Richard S Cooper, Bamidele Tayo, Guillaume Lettre, Jeanne Ngogang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3965431?pdf=render