Altered Humoral Immune Responses and IgG Subtypes in NOX2-Deficient Mice and Patients: A Key Role for NOX2 in Antigen-Presenting Cells

Altered Humoral Immune Responses and IgG Subtypes in NOX2-Deficient Mice and Patients: A Key Role for NOX2 in Antigen-Presenting Cells

Chronic granulomatous disease (CGD) is a primary immunodeficiency resulting from loss of function mutations in the reactive oxygen species generating phagocyte NADPH oxidase (NOX2). CGD patients are prone to infection, but also have an increased susceptibility to autoimmune diseases. The aim of this...

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Bibliographic Details
Main Authors: Julien Cachat, Christine Deffert, Marco Alessandrini, Pascale Roux-Lombard, Audrey Le Gouellec, Marie-José Stasia, Stéphanie Hugues, Karl-Heinz Krause
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Immunology
Subjects:
NOX2
B cells
T cells
immunoglobulin
antigen-presenting cells
curdlan
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01555/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.01555/full

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