Synthesis and Biological Evaluation of Imidazo[2,1-<i>b</i>]Thiazole based Sulfonyl Piperazines as Novel Carbonic Anhydrase II Inhibitors

Synthesis and Biological Evaluation of Imidazo[2,1-<i>b</i>]Thiazole based Sulfonyl Piperazines as Novel Carbonic Anhydrase II Inhibitors

A novel series of imidazo[2,1-<i>b</i>]thiazole-sulfonyl piperazine conjugates (9aa-ee) has been synthesized and evaluated for carbonic anhydrase (CA, EC 4.2.1.1) inhibitory potency against four isoforms: The cytosolic isozyme hCA I, II and trans-membrane tumor-associated isoform hCA IX...

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Bibliographic Details
Main Authors: Kesari Lakshmi Manasa, Sravya Pujitha, Aaftaab Sethi, Mohammed Arifuddin, Mallika Alvala, Andrea Angeli, Claudiu T. Supuran
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Metabolites
Subjects:
carbonic anhydrase
hCA I
hCA II
hCA IX
hCA XII
imidazo[2,1-<i>b</i>]thiazole
Online Access:https://www.mdpi.com/2218-1989/10/4/136

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https://www.mdpi.com/2218-1989/10/4/136

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