Hemin activation abrogates Mycoplasma hyorhinis replication in chronically infected prostate cancer cells via heme oxygenase‐1 induction

Hemin activation abrogates Mycoplasma hyorhinis replication in chronically infected prostate cancer cells via heme oxygenase‐1 induction

Mycoplasma hyorhinis (M. hyorhinis) lacks a cell wall and resists multiple antibiotics. We describe here the striking > 90% inhibitory effect of hemin, a natural inducer of the cytoprotective enzyme heme oxygenase‐1 (HO‐1), on M. hyorhinis replication in chronically infected LNCaP prostate cancer...

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Bibliographic Details
Main Authors: Hanxia Huang, Alena Dabrazhynetskaya, Jacob Pluznik, Jiwen Zheng, Yong Wu, Vladimir Chizhikov, Paul W. Buehler, Kenneth M. Yamada, Subhash Dhawan
Format: Article
Language:English
Published: Wiley 2021-10-01
Series:FEBS Open Bio
Subjects:
heme oxygenase‐1
host defense
infectious disease
innate immunity
Mycoplasma hyorhinis
prostate cancer
Online Access:https://doi.org/10.1002/2211-5463.13271

Internet

https://doi.org/10.1002/2211-5463.13271

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