Silencing MicroRNA-134 Alleviates Hippocampal Damage and Occurrence of Spontaneous Seizures After Intraventricular Kainic Acid-Induced Status Epilepticus in Rats

Silencing MicroRNA-134 Alleviates Hippocampal Damage and Occurrence of Spontaneous Seizures After Intraventricular Kainic Acid-Induced Status Epilepticus in Rats

Epilepsy is a disorder of abnormal brain activity typified by spontaneous and recurrent seizures. MicroRNAs (miRNAs) are short non-coding RNAs, critical for the post-transcriptional regulation of gene expression. MiRNA dysregulation has previously been implicated in the induction of epilepsy. In thi...

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Bibliographic Details
Main Authors: Xiaoying Gao, Mian Guo, Dawei Meng, Feixiang Sun, Lianyue Guan, Ying Cui, Yan Zhao, Xichun Wang, Xin Gu, Jiahang Sun, Sihua Qi
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Cellular Neuroscience
Subjects:
microRNA-134
hippocampal neurons
oxidative stress
epilepsy
CREB
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2019.00145/full

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https://www.frontiersin.org/article/10.3389/fncel.2019.00145/full

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