A natural histone H2A variant lacking the Bub1 phosphorylation site and regulated depletion of centromeric histone CENP-A foster evolvability in Candida albicans.

A natural histone H2A variant lacking the Bub1 phosphorylation site and regulated depletion of centromeric histone CENP-A foster evolvability in Candida albicans.

Eukaryotes have evolved elaborate mechanisms to ensure that chromosomes segregate with high fidelity during mitosis and meiosis, and yet specific aneuploidies can be adaptive during environmental stress. Here, we identify a chromatin-based system required for inducible aneuploidy in a human pathogen...

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Bibliographic Details
Main Authors: Cedric A Brimacombe, Jordan E Burke, Jahan-Yar Parsa, Sandra Catania, Teresa R O'Meara, Jessica N Witchley, Laura S Burrack, Hiten D Madhani, Suzanne M Noble
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-06-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.3000331

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https://doi.org/10.1371/journal.pbio.3000331

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