B cell recognition of the conserved HIV-1 co-receptor binding site is altered by endogenous primate CD4.

B cell recognition of the conserved HIV-1 co-receptor binding site is altered by endogenous primate CD4.

The surface HIV-1 exterior envelope glycoprotein, gp120, binds to CD4 on the target cell surface to induce the co-receptor binding site on gp120 as the initial step in the entry process. The binding site is comprised of a highly conserved region on the gp120 core, as well as elements of the third va...

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Bibliographic Details
Main Authors: Mattias N E Forsell, Barna Dey, Andreas Mörner, Krisha Svehla, Sijy O'dell, Carl-Magnus Högerkorp, Gerald Voss, Rigmor Thorstensson, George M Shaw, John R Mascola, Gunilla B Karlsson Hedestam, Richard T Wyatt
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-10-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC2542413?pdf=render

Internet

http://europepmc.org/articles/PMC2542413?pdf=render

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