B cell recognition of the conserved HIV-1 co-receptor binding site is altered by endogenous primate CD4.
The surface HIV-1 exterior envelope glycoprotein, gp120, binds to CD4 on the target cell surface to induce the co-receptor binding site on gp120 as the initial step in the entry process. The binding site is comprised of a highly conserved region on the gp120 core, as well as elements of the third va...
Main Authors: | , , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2008-10-01
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Series: | PLoS Pathogens |
Online Access: | http://europepmc.org/articles/PMC2542413?pdf=render |