GLP-1 mediated diuresis and natriuresis are blunted in heart failure and restored by selective afferent renal denervation

GLP-1 mediated diuresis and natriuresis are blunted in heart failure and restored by selective afferent renal denervation

Abstract Background Glucagon-like peptide-1 (GLP-1) induces diuresis and natriuresis. Previously we have shown that GLP-1 activates afferent renal nerve to increase efferent renal sympathetic nerve activity that negates the diuresis and natriuresis as a negative feedback mechanism in normal rats. Ho...

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Bibliographic Details
Main Authors: Kenichi Katsurada, Shyam S. Nandi, Hong Zheng, Xuefei Liu, Neeru M. Sharma, Kaushik P. Patel
Format: Article
Language:English
Published: BMC 2020-05-01
Series:Cardiovascular Diabetology
Subjects:
Glucagon-like peptide-1
Renal afferent
Sympathetic nerve activity
Sodium and water homeostasis
Heart failure
Online Access:http://link.springer.com/article/10.1186/s12933-020-01029-0

Internet

http://link.springer.com/article/10.1186/s12933-020-01029-0

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