EZH2 codon 641 mutations are common in BCL2-rearranged germinal center B cell lymphomas.

EZH2 codon 641 mutations are common in BCL2-rearranged germinal center B cell lymphomas.

Mutations at codon 641 of EZH2 are recurrent in germinal center B cell lymphomas, and the most common variants lead to altered EZH2 enzymatic activity and enhanced tri-methylation of histone H3 at lysine 27, a repressive chromatin modification. As an initial step toward screening patients for cancer...

Full description

Bibliographic Details
Main Authors: Russell J H Ryan, Mai Nitta, Darrell Borger, Lawrence R Zukerberg, Judith A Ferry, Nancy Lee Harris, A John Iafrate, Bradley E Bernstein, Aliyah R Sohani, Long Phi Le
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22194861/?tool=EBI

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22194861/?tool=EBI

Similar Items