Association of Aβ deposition and regional synaptic density in early Alzheimer’s disease: a PET imaging study with [11C]UCB-J

Association of Aβ deposition and regional synaptic density in early Alzheimer’s disease: a PET imaging study with [11C]UCB-J

Abstract Background Attempts to associate amyloid-β (Aβ) pathogenesis with synaptic loss in Alzheimer’s disease (AD) have thus far been limited to small numbers of postmortem studies. Aβ plaque burden is not well-correlated with indices of clinical severity or neurodegeneration—at least in the demen...

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Bibliographic Details
Main Authors: Ryan S. O’Dell, Adam P. Mecca, Ming-Kai Chen, Mika Naganawa, Takuya Toyonaga, Yihuan Lu, Tyler A. Godek, Joanna E. Harris, Hugh H. Bartlett, Emmie R. Banks, Victoria L. Kominek, Wenzhen Zhao, Nabeel B. Nabulsi, Jim Ropchan, Yunpeng Ye, Brent C. Vander Wyk, Yiyun Huang, Amy F. T. Arnsten, Richard E. Carson, Christopher H. van Dyck
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Alzheimer’s Research & Therapy
Subjects:
SV2A
Synaptic density
Aβ
Alzheimer’s disease
[11C]UCB-J PET
[11C] PiB PET
Online Access:https://doi.org/10.1186/s13195-020-00742-y

Internet

https://doi.org/10.1186/s13195-020-00742-y

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